Aller à translateinthetownships.comBtKInhibitorbtkinhibitor
BTK (Bruton's tyrosine kinase) also known as tyrosine-protein kinase BTK is an enzyme that in humans is encoded by the BTK gene. BTK is a kinase that plays a crucial role in B-cell development. Its exact mechanism of action remains unknown, but it plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor. Btk contains a PH domain that binds phosphatidylinositol (3, 4, 5)-trisphosphate (PIP3). PIP3 binding induces Btk to phosphorylate phospholipase C, whi
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